The volume control rocker on my Pixel XL frequently stops working. I don't have the "loose" rocker button I've seen people complain about with this phone, it just doesn't respond to input - doesn't matter if I want to change the ringer volume or if I'm trying to adjust media playback volume. Doesn't matter whether the screen's on or off. Once it stops responding, it will not work again until I reboot the phone, otherwise I have to go into settings to adjust volume which is unacceptable. I've had the phone for barely a month, I haven't dropped it or damaged it in any other way. It stays in a case and I've made sure that dust and whatnot are not an issue.
I can confirm I have latest updates, etc.