I posted this as a reply in another thread about problems with email after ICS update. This worked for me, hopefully it will work for you if you are having the same problem.
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I was having problems with my email app on DROID RAZR after ICS OS update. Here is what I did to fix it.
Disable the gmail app to get the regular email app to work. Go in to apps, gmail app, force stop, uninstall updates, disable app. Then go back to the regular email app and set up your accounts. Something about the gmail app is overwriting or taking over the regular email app.
I just did this and was able to set up sync and 5 minute checks for both my comcast and hotmail accounts. Seems like it's working OK so far.
Also, I set up my hotmail account by selecting manual, not by selecting the windows live hotmail option.
Hope this helps. I was pretty frustrated (ok pissed) that I couldn't get email on my "smart" phone.
I'll post this in it's own thread, hopefully to help others too.