I've had this problem with my rezound before i got a replacement and after.
Whenever I hold the phone with my left hand, the signal is distorted to the point that my parents and friends can't understand a word I say. I've tried different locations and different ways to hold the phone with my left and and it ALWAYS messes up. Immediately upon switching to my right hand, the problem goes away. I hold it the same way in both hands. Has ANYONE else had this problem and is there a solution out there?